Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Identifying the challenges of online education from the perspective of University of Medical Sciences Students in the COVID-19 pandemic: a Q-methodology-based studyArticle Published on 2022-12-272023-07-11 Journal: BMC Medical Education [Category] COVID19(2023년), [키워드] challenge online education Q methodology student. [DOI] 10.1186/s12909-022-03980-w PMC 바로가기
SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in MiceArticle Published on 2022-11-012022-11-15 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome ancestral antibody Australia challenge coronavirus coronavirus disease COVID-19 cross-protection cross-reactivity Delta elicited homologous immunogenicity Infection K18-hACE2 K18-hACE2 mice mice Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron BA.1 remained respiratory infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe acute respiratory syndrome coronavirus 2 Strains vaccine-preventable diseases viruses zoonoses zoonoses. [DOI] 10.3201/eid2811.220718 PMC 바로가기
Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2PArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Beta challenge coronavirus COVID-19 COVID-19 vaccine Delta dose Effectiveness hamster hamster challenge study highest live SARS-CoV-2 Live virus lung MVC-COV1901 neutralization Neutralizing antibody titer Omicron variant pathology prefusion PROTECT pseudovirus recombinant regimen S-2P SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 vaccine spike Spike protein subunit Subunit vaccine suggested vaccination Vaccines variant Variant of concern. variants variants of concern virus Wuhan [DOI] 10.1093/infdis/jiac153 PMC 바로가기
Challenges of vaccination and herd immunity in COVID-19 and management strategiesArticle Published on 2022-11-012022-11-16 Journal: The clinical respiratory journal [Category] SARS, 변종, [키워드] acute respiratory syndrome caused challenge contagious coronavirus Coronavirus disease 2019 country COVID-19 COVID-19 vaccination COVID-19 vaccine Critical death Defense effective eligible help herd immunity Hospitalization Immunity management mutant Outbreaks prevention PROTECT reduce reducing risk SARS-CoV-2 SARS-CoV-2 variant severe disease Spread susceptible the disease vaccination vaccination. variants viral disease virus [DOI] 10.1111/crj.13543 PMC 바로가기
Challenges in diagnosing COVID-19 related disease in pediatric patients with rheumatic diseaseArticle Published on 2022-10-152022-11-15 Journal: Modern rheumatology [Category] 진단, [키워드] abdominal pain Administered Anakinra challenge chest pain children clinical Clinical characteristics coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 dermatomyositis diagnosing Diagnosis disease elevated evaluated Features Fever fraction function Immunoglobulin infiltration Inflammatory Inflammatory marker juvenile idiopathic arthritis Laboratory Mediterranean fever Methylprednisolone MIS-C multisystem inflammatory syndrome in children (MIS-C) myalgia outcome overlap Patient patients Pediatric patient Pneumonia raise Rash Rheumatic disease. Rheumatic diseases Symptom syndrome the patient [DOI] 10.1093/mr/roab112 PMC 바로가기
Immunogenicity, Safety, and Anti-Viral Efficacy of a Subunit SARS-CoV-2 Vaccine Candidate in Captive Black-Footed Ferrets ( Mustela nigripes) and Their Susceptibility to Viral ChallengeArticle Published on 2022-10-042022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Affect Anti-viral Antibody Response Antibody titer black-footed ferrets candidate challenge clinical disease correlated declined Efficacy experimental challenge ferret highest Human immunogenicity in vitro in vivo increase in indicate lack lung viral load mice morbidity Mortality mustelids pathogen populations potential risk pre-vaccination produced Protein purified Safety SARS-CoV-2 SARS-CoV-2 S1 serum subunit susceptibility transfer Trial unlikely upper respiratory tract vaccination vaccination. vaccinees viral replication was determined [DOI] 10.3390/v14102188 PMC 바로가기
Challenges of data sharing in European Covid-19 projects: A learning opportunity for advancing pandemic preparedness and responseReview article Published on 2022-10-012022-10-05 Journal: The Lancet Regional Health - Europe [Category] 유전자 메커니즘, [키워드] approval challenge cohort study cohorts Compliance COVID-19 pandemic Critical data curation Data sharing European GDPR General Data Protection Regulation International machine learning mandatory Metadata National pandemic Patient Preparedeness producing protection public health recommendation Research SARS-CoV-2 submission Support [DOI] 10.1016/j.lanepe.2022.100467 [Article Type] Review article
Challenges in the Detection of SARS-CoV-2: Evolution of the Lateral Flow Immunoassay as a Valuable Tool for Viral DiagnosisArticle Published on 2022-09-052022-11-15 Journal: Biosensors [Category] SARS, 진단, 치료기술, [키워드] affected antibodies biosensors caused challenge coronavirus disease COVID-19 deaths detect detection Diagnosis diagnosis of SARS-CoV-2 diagnostic Evolution Flow Health immunoassay infected patient Infectious disease Lateral lateral flow immunoassay lateral flow immunoassay. LFIA limitations outbreak pandemic SARS-CoV-2 Sensitivity and specificity Spread the SARS-CoV-2 triggered virus virus zoonotic origin [DOI] 10.3390/bios12090728 PMC 바로가기
Challenges of addressing neglected tropical diseases amidst the COVID-19 pandemic in Africa: A case of Chagas DiseaseCorrespondence Published on 2022-09-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 진단, [키워드] affected Africa approaches article Atrial fibrillation Cardiomyopathy caused Chagas disease challenge change chronic heart failure clinical guideline Clinical management Co-infection Comorbidity condition coronavirus disease coronavirus SARS-CoV-2 country COVID-19 COVID-19 pandemic diagnostic disease effort exacerbate Google Scholar higher risk Impact inclusion criteria mitigate neglected tropical diseases NTD NTDs pandemic Patient patients preventive measure public health resources Spread subsequent treat Treatment tropical Vaccine [DOI] 10.1016/j.amsu.2022.104414 [Article Type] Correspondence